That Roche was (IMO) willing to pay $175M to get out of the ITMN agreement tells me that Roche considers a protease inhibitor an obligate component of an all-oral HCV cocktail.
Agreed.
I know Roche had previously licensed ITMN's 2nd/3rd gen HCV PI, which isn't even in the clinic yet. I assume that agreement is still in place as today's news only appeared to pertain to ITMN-191. Did the HCV PI exclusivity arrangement pertain strictly to ITMN-191 or did it also involve the 2nd/3rd gen HCV PI? Just curious if we would need to see Roche also cancel the agreement with ITMN regarding the 2nd/3rd gen HCV PI before we would expect Roche to seek out a PI from another company.