I also find your blanket dismissal of ligand inhbitors amusing
Get a clue.
This entire conversation is related to Curis' GDC-0449 and it's action on the pathway. Not a "blanket" on ligand inhibitors.
So, you think Curis' CEO and Roche don't differentiate between mutation-driven and ligand-driven? LOL, maybe you should read the data from both parties, presentations, and the SEC filings, etc.