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Re: MotionMan post# 101511

Thursday, 08/12/2010 11:31:29 PM

Thursday, August 12, 2010 11:31:29 PM

Post# of 257253

Which companies are possible [M118] suitors then?

Any company not listed in #msg-53281197 is presumably a candidate.

What kind of upfront payment and % split can they expect to receive from a M118 deal?

You can look at the Apixaban and Betrixaban deals for guidance.

In the Apixaban deal (#msg-19134406), BMY:

• received $250M up-front from PFE;
• is eligible to receive $750M in clinical/regulatory milestones;
• pays 40% of worldwide development costs; and
• will receive 50% of worldwide net profits.

In the Betrixaban deal (#msg-39388813), Portola:

• received $50M up-front from MRK;
• is eligible to receive $420M in clinical/regulatory/sales milestones;
• pays none of the development costs;
• will receive a double-digit % royalty on worldwide sales.

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