The virologic-failure rate difference was higher in ECHO trial (11.0% vs 4.4%) than in THRIVE (7.1% vs 5.3%), and there's no explanation for this either.
The disparity between the VF deltas of the two trials wasn’t statsig, as far as I know. It looks like routine statistical noise.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”