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Re: DewDiligence post# 7180

Sunday, 01/30/2005 10:31:48 PM

Sunday, January 30, 2005 10:31:48 PM

Post# of 257273
"Could these molecules be eluted from a device?"

I think elution is the way to go with Macugen. I'm not sure it would be effective with TrpRS. Where is the receptor for TrpRS? If it's intracellular, then bathing tissue in the protein probably won't be effecteve. In this case a gene-therapy approach would be better (using particle- or viral-based delivery of DNA endoding the TrpRS fragment to the target tissue).

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