World’s Top-Selling HIV Drugs [pre] 2009 $B Date FDA Drug Company sales approved Class(classes) Truvada GILD 2.49 2004 purine nuke/pyrimidine nuke Atripla GILD/BMY 2.38 2006 purine nuke/pyrimidine nuke/non-nuke Reyataz BMY 1.40 2003 PI Kaletra ABT 1.37 2000 PI Sustiva BMY 1.28* 1998 non-nuke Epzicom ViiV† 0.86 2004 purine nuke/pyrimidine nuke Isentress MRK 0.75 2007 integrase inhibitor Viread GILD 0.67 2001 purine nuke Combivir ViiV 0.67 1997 two pyrimidine nukes Prezista JNJ 0.59 2006 PI Epivir ViiV† 0.54 1995 pyrimidine nuke *Includes 37% of Atripla sales. †Joint venture of GSK and PFE. [/pre]Source: http://www.reuters.com/assets/print?aid=CNLDE66C0FR20100719; I corrected the table for the omission of Sustiva and added the drug-class column.