Low dose Qnexa has efficacy in the same range of Lorcaserin not better, but Lorcaserin still got a better AE profile compared to low dose Qnexa. There is no doubt the drug is tolerable enough, (18% vs 8% placebo drop out rate) if you don't drop out during the titration period. However, there is no question Qnexa causes more side effects than Lorcaserin. My bet is doctors will try a drug with less side effects before moving patients to combo therapy that comes in with more side effects especially when patients need to go through a one month titration period.