Phen is not safe. You need to sign a wavier form or else your doctor most likely will not prescribe it to you. Topomax was dropped by JNJ for the obesity indication due to safety concerns (mental dullness and tingling in fingers). The drop out rate of Qnexa due to adverse events far exceeds placebo. Not to remind you these are patients who went through 1 month of titration period and find it tolerable enough to continue. Also patients with high blood pressure were excluded from the trial as well due to the phen composition. If I recall correctly 15-20% of patients experienced insomnia, dry mouth, paresthesia, altered tastes, and constipation. Again, this is after the titration period. I wonder what the data would look like if the patients who dropped out during titration period were included in their final analysis.