Biotech Values

[DewDiligence]

>>Squalamine may not be effective as intravitreal injection.<<

When treating a small organ such as the eye, it’s unusual to have a drug show more efficacy administered systemically rather than locally. Perhaps this odd finding was caused by the idiosyncrasies of the laser-induced neovascularization used in animal models, which is not always a good guide for the “natural” neovascularization that causes AMD.

Also, I wonder if clever medicinal chemistry couldn’t have circumvented whatever the problem was with local administration.