Isolution,
I get most of your point, but the clarity of your writing leaves something to be desired.
Can you explain the statement "all of the players in the field (Oxigene, Eyetech, Alcon, Allergan, SiRNA...) have made the choice for local DD and pursue research in the field for an alternative to needlestick,..."
What research are these companies doing for an alternative to needlestick that you actually know of? What alterntives exactly are you referring to?
Bladerunner