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Saturday, June 05, 2010 6:37:55 AM

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ASCO - Saturday June 5,

Long-term outcomes of responders in a randomized, controlled phase II trial of aptamer AS1411 in AML.

Sub-category: Leukemia
Category: Leukemia, Myelodysplasia, and Transplantation
Meeting: 2010 ASCO Annual Meeting
Citation: J Clin Oncol 28:7s, 2010 (suppl; abstr 6557)

Abstract No: 6557

Session: Leukemia, Myelodysplasia, and Transplantation
Type: General Poster Session
Time: Saturday June 5, 8:00 AM to 12:00 PM
Location: S Hall A2


This phase II trial suggested that addition of AS1411 to cytarabine may enhance anti-leukemic activity and that the combination has an acceptable safety profile in patients with relapsed and refractory AML.
Follow-up suggests substantial survival durations in some patients responding to AS1411 + cytarabine.
A phase IIb study is now evaluating responses, duration of responses and survival in AML patients randomized to AS1411 + cytarabine or cytarabine alone.
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