Biotech Values

[DewDiligence]

Re: Long-term safety

This post from Yahoo (#60290) connects more dots that perhaps need connecting:

Re: Both eyes safely (maybe)
by: DewDiligence
01/11/05 05:23 am
Msg: 60290 of 60293

>>By the way, the dosing safety issues that Dew has mentioned are not an issue at all. The cancer trials of around 400mg/m2 more than once a week I believe, 10 times that in these trials, never showed a problem.<<

What you’re missing is this: short-term safety at high doses does not imply long-term safety at low doses.

The Squalamine trials in cancer treated patients for a short duration and then followed the patients (without additional treatment) for an extended duration. Hence, these cancer trials did not provide definitive data on safety for the kind of long-term, repeated treatment required in AMD.