>>DEW: How important is it that lower doses would be effective? <<
That’s the $64,000 question.
What we can say with some assurance is that the FDA thinks these lower doses matter to some degree, else they would not have been included in the “209” monotherapy trial (which tests 20-40mg) and the “208” combo trial (which tests 10-40mg).
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”