AIS explained the rational during their last CC… 1. Methotrexate is co-prescribed with alot of biologics given to treat RA at home. 2. IM injection is approved, but most individuals go to the docs office for their injection. 3. Once you start titrating higher levels of oral methotrexate 12-15 milligrams its not as effectively absorbed in gastro tract (sub-therapeutic level) & you start getting some adverse effects.
I don’t see how any of this makes a non-substitutable injectable more than a tiny-selling product.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”