Addendum re ACH-1625 data in #msg-50044485: It’s curious that the control arms in all four cohorts showed a reduction in viral load of 0.22-0.29 logs* after five days of “dosing” with nothing but a sugar pill. Insofar as VL measurements are empirical rather than subjective, I find it surprising that all four cohorts showed a placebo benefit and that the placebo VL reductions fell within a tight range.
*In the table in #msg-50044485, subtract the number in the fifth column from the number in the fourth column to get the mean-log placebo response for each cohort.
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