I asked IJ about it (either here or on SI) and he seemed reluctant to to go with it. I guess safety will be the big concern with Campath in MS and may prevent it from becoming a front-line therapy. I wonder if at some efficacy level some MS patients would try it ahead of other therapies despite the risks? On an analyst day (maybe a couple years ago) Henri claimed that monitoring could help with the risks but his creditability is suspect (especially these days).