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Re: DewDiligence post# 94177

Wednesday, 04/14/2010 9:49:19 PM

Wednesday, April 14, 2010 9:49:19 PM

Post# of 252489
BAX-Gammagard:

I read the results and had a couple of thoughts/questions including:

How frequent are the infusions? (there are several in trials right now, I believe, and the hassle of frequency will be telling.)

BAX provided a very small sample size and I have seen plenty of DAT studies with small sample size stat sig results that just disappear when the larger samples are taken.

This was a PR about results and I want to read the paper to see if/how many dropouts occurred to get to the 14 treated/7 control patients. The PR had general information about SE's but nothing about frequency for the study population.

Cortical atrophy/ventricular enlargement measures have not been part of the standard fare in the past and the data are intriguing, but the decline in ADAS scores for treatment patients are grossly in line with Aricept studies if memory serves. If you can get the same results with a daily oral med, then why go to all the fuss?

aj

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