Hi Connie. Yes, highly sensitive C-Reactive Protein should be included in routine blood analysis along with others. Inflammation is a huge killer. However, my CRP (as well as many other patients) has never been high but my homocysteine was very high. P-5-P (pyridoxal-5-phosphate) the active form of vitamin B6 is the cofactor for the enzyme that helps breakdown homocysteine. P-5-P alone did not help me but combined with betaine (trimethylglycine - a methyl donor), and methylcobalamin (NOT CYANOCOBALAMIN), I was able to lower from 23 down to 8. This helped recycle homocysteine back to methionine and helps the folic acid cycle in general. High homocysteine not only causes cardiovascular disease but has been linked to neurodegenerative brain disease incl: Alzheimer's, dementia, eetc... Keep in mind, some people have a SNIP (single nucleotide polymorphism), a genetic defect regarding the conversion of B6 to the active form: pyridoxal-5-phosphate(most important vitamin in body, biochemically - imo). These people have a life-long P-5-P defficiency and because it is involved in the synthesis of many neurotransmitters incl. dopamine, serotonin, etc... the first notable symptom in most patients is depression/anxiety/emotional problems. I meant to speak with a woman at Pheonix Monkinar who was having some problems - do you remember her name? You can check urinary neurotransmitters to get an idea what is going on in the brain instead of guessing with meds.