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Re: mcbio post# 93795

Friday, 04/09/2010 9:45:48 AM

Friday, April 09, 2010 9:45:48 AM

Post# of 252289
Regarding PYMX...

With respect to the numbness/tingling, it was indicated that the effect was seen out to 10 days post treatment in certain instances. Is that cause for any type of concern? That seems strange that there would still be a numbness/tingling sensation out to 10 days post treatment. Even though this doesn't appear to be a concern now, I wonder if this could be signs of a more worrisome side effect that might occur in a longer duration, or different type of, study. Any thoughts are appreciated here.



The drug likely won't be dosed longer 1x/day than 7-14 days, so cumulative tox is unlikely to be much of a problem beyond the 10 doses we've already seen. The big test for both side effects is to see if they worsen in actual patients. Remember, the drug hasn't been in infected patients yet.

I understand that PMX-30063 is patterned after human defense proteins. How has PMX-30063 been designed to succeed where natural human defense proteins fail? Is it simply a matter of PMX-30063 being many fold more potent than natural human defense proteins or is there some major structural difference that leads PYMX to believe that PMX-30063 can succeed against bacterial infections where natural human defense proteins fail?



This is a good question. Again, while this looks really promising there is no data in real patients yet. We initiated formal coverage on the company back in January. The biggest issue is that the programs are very early with little data in actual patients for either drug, but especially the antibiotic. Patience and patients, as a wise man I know once said, will reveal whether they indeed have something here.

Unless otherwise indicated, this is the personal viewpoint of David
Miller and not necessarily that of Biotech Stock Research, LLC.
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