Under the "technical definition," ACH-2684 is protease or protease-like, but it is very different structurally and in terms of its activity compared to other PIs.
hmm - what could this novel structure possibly be? already both linear (telaprevir) and macrocyclic proteases (itmn, idix) are in the clinic..and in terms of activity you now have a protease that has pan-genotypic activity (idix-320) - so what left is there in terms of differentiated activity for a protease?
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