i think gammagard is a very dark horse. the costs to manufacture are very high, drug pricing will be a concern. also, by 2014, another 3 potential disease modifying drugs have a chance to get to market: Bapineuzumab Lilly's Gamma secretase inhibitor Lilly antibody solaneuzumab but in last 3 years: alzhemed and flurizan and now dimebon have failed ph 3