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dewophile

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dewophile

Re: DewDiligence post# 89986

Tuesday, 02/02/2010 12:57:50 PM

Tuesday, February 02, 2010 12:57:50 PM

Post# of 252484
re new achn PI

Anything longer than what is needed for qD dosing is immaterial from a commercial standpoint



you can even make an argument that a very long half life is a negative since it would take longer for toxicities to resolve upon discontinuation should AEs emerge. i'm also not quite sure what the implications would be for conformulation since it would take much longer to reach steady state than other compounds in a combination pill
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