…I do not agree that the "third agent paradigm" is here to stay indefinitely. Truvada may be the cleanest nuke but there are cleaner classes now, so I wouldn't be surprised to see nuke-sparing regimens come to dominate first line at some point because of improved tolerability.
According to GILD’s 4Q09 CC yesterday, Truvada is used by 81% of Isentress patients and 91% of Prezista patients in the first-line setting. If anything, the Truvada “paradigm” appears to be strengthening rather than weakening as new HIV agents are added to the armamentarium. Regards, Dew
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”