Dew. Thanks for the reply. It could be expected that an anti-angiogenesis injected systemically could affect blood vessels randomly. I understand that the 10mg was also tested to provide easier delivery; although maybe not local delivery. The fact that the FDA granted fast-track to squalamine goes counter to the idea that side-effects worries them much, however. I recall that a number of specialists had argued fast-track would not be possible for an anti-angiogenesis in AMD. I only have a small position so I am not utterly worried myself, but do hope this works.