Randy Re: "I fail to see how a cherry picked set of patients would allow patients vision to improve as they did in that study. If they had wet amd, and their vision improved, it was squalamine that did that was reason. Any arguement there?"
If one has seen many AMD patients, it may be possible to observe a stage when the preception of loss of vision fluctuates the most, unless the endpoint was only an observed measured biological molecular measurable modality. If as I assume, that the test was based only on subjective chart reads, this method could be prone to unintended biases, both in patient selection and posited testing results.
But I do remember something about microscopic vessel observations or am I connecting this with another study????