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Re: DewDiligence post# 88116

Wednesday, 12/23/2009 7:58:15 PM

Wednesday, December 23, 2009 7:58:15 PM

Post# of 257262
PSDV -

By the ART analysis, in Trial A 26.8% of low dose patients and 26.2% of high dose patients gained 15 or more letters at 24 months compared with 14.7% of patients randomized to control (p = 0.029 and 0.032, respectively). In Trial B of the ART analysis 30.8% of low dose patients and 31.3% of high dose patients gained 15 or more letters compared with 17.8% of control patients (p = 0.028 and 0.026, respectively). The results for both doses in both trials were statistically significant.



My initial assumption was what you wrote. However the above refutes that assumption unless the standard ART analysis implies that there is no requirement to divide the p value.

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