Biotech Values

[biomaven0]

Re:PYMX

any concerns about the "warmth" and "itching" side effect of the drug?

I'll take warmth and itching over the occasional death from an infusion reaction or hypotensive crisis that you can get with protamine.

Warmth and itching are not uncommon side effects from infusing even benign drugs. So what they have reported to date doesn't concern me. I have no reason to believe it is likely get worse on repeat dosing, and maybe even something as simple as slowing down the infusion might prevent it.

This is still a very early stage program. But at this point, to my mind efficacy for non-bypass heparin reversal has pretty much already been established. Next they need to try some LMWHs and high-dose heparin reversal. I'm pretty sure those too will work, and so really safety remains the outstanding issue. But the drug's not for chronic use and will be compared with another drug that has known warts, so the bar is not all that high. Still until the drug has been in a few thousand patients nobody really can tell what might emerge.

It's really way to early for them to talk about partnering so I'm not surprised they didn't.