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Re: mcbio post# 87563

Tuesday, 12/15/2009 9:26:54 PM

Tuesday, December 15, 2009 9:26:54 PM

Post# of 257579
ACHN:

I'm curious how the mean 5-day log drop of 3.94 log10 compares to telaprevir and the other PIs. There is no way to do an apples-to-apples comparison I assume as most of the other HCV PIs measured their initial PoC potency data at 3 days I believe.

If I recall correctly, the FDA’s 3-day limit on monotherapy testing was not yet in effect when Telaprevir was in phase-1b; hence, there may be some Telaprevir data we can use for comparison purposes. I’ll do some checking and you can too.


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