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Re: rkrw post# 86220

Friday, 11/13/2009 12:01:04 PM

Friday, November 13, 2009 12:01:04 PM

Post# of 257253
ZGEN - HCV drug values Bristol is so Bristol shelling out so much money for lambda. I don't get it.

What seems odd to you about the ZGEN/BMY deal? The direct anti-viral HCV drugs are getting deals in the same ballpark ...

1) Market penetration odds for any given direct antiviral are, perhaps, 30% chance of 70% market share - where the 30% comes because there are so many antivirals in development (say 10 different drugs and 3 will make it to the big leagues in a triplet therapy)

2) Market penetration odds for IFN-L are, perhaps, 30% chance of 90% market share - where the 30% comes just because the consensus is that IFN will be obsoleted.

Note that in neither case did I discount for SAE issues, ... . Also note that I personally believe that the odds of still needing IFN after the direct anti-virals come on board is better than 30%. But I chose to be conservative to show the logic.

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