"Question - why exclude SVR? SVR has undoubtedly also been a moving target so I would expect that a 50% SVR rate of 5 years ago (using an assay of <300?) would look somewhat different now (using an assay of <50)? It may not be as large a number changer as in RVR - but I'll bet it makes a difference of at least 10% (of the SVR rate) over the period of time since SVR first started being used."
i don't think SVR would change measurably with newer assays. SVR (using old assays) is associated with long term (multi-year) suppression of virus. thus, if there was residual virus below the lower limit of detection of old assays SVR would not equate with a cure 99% of the time
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