Avid Bioservices Inc (CDMO)

[entdoc]

wook,whatcha mean,"once the body recognizes the cancer it is programmed."?
Some cancers are weakly/minimally immunogenic...ie...they do not tilt the body's alarm system when getting established. Glioma is one. Sarcoma is another. In this case, Bavi seems to increase body's immune-police response to second exposure to tumor, and evenly weakly immunogenic tumors. Thorpe postulates that "[Bavi] induced immunity to[reimplanted] tumor cells is [via enhanced] dendritic cells that help generate specific [killer] T cells.
We know that irradiation and chemotherapy causes more PS inversion. Another conclusion Thorpe draws from this work is that since PS is seen on cancer cells naturally, and is increased during chemo- and irradiation treatment, the membrane PS is acting AGAINST body immune defenses. The PS likely suppresses tumor immunogenicity, and 2aG4 blocks this tolerogenic effect...i.e. unblocks the body's immune response.