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Re: go seek post# 85559

Thursday, 10/29/2009 9:02:32 PM

Thursday, October 29, 2009 9:02:32 PM

Post# of 257257
idix

"Any guesses on who Idenix may be talking to?"

i think MRK/SGP has to be at the top of the list. 184 would be a great fit with boceprevir (why wait for their own polymerase to reach the clinic and be that much further behind roche and gild)

i think gild and vrtx should take a hard look, but if they seem sold on the fact a non-nuc is enough of a complement to their protease then they might not be biting

another player that i think would be high on the list is actually BMY. their NS5A inhibitor is much like a protease - high potency and (presumably) low resistance. complementing that type of drug with a lower potency higher barrier to resistance drug makes sense. they also have a protease in the preclinical stage

certainly there are other potentials, but one company that surely doesn't need 184 is roche (unless their current nuc bombs on renal tox)

PS: fwiw i think NVS would NOT have made as good a fit as some of the others i mentioned
PPS: a partnership may not be consummated until some 14 day data emerges

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