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Re: ghmm post# 85457

Tuesday, 10/27/2009 9:52:00 PM

Tuesday, October 27, 2009 9:52:00 PM

Post# of 257257
Re: VX-813/VX-985/ITMN-191

Don't want to speak for Dew by my thinking is they are dead because of side-effect or viral load reductions not being up to par with competitors compounds in Phase 1-2.

But VRTX doesn't have any clinical data in hand yet to make this call do they? Perhaps they just saw something pre-clinically that caused them to drop the compounds.

It would be huge for ITMN/Roche if BID Telaprevir is a flop and Ritonavir+191 allows for QD dosing (but I'll be happy with lower BID dosing).

That should certainly be a good advantage if all other things are at least equal. How much does Ritonavir add to the cost of treatment? Would 191+Ritonavir QD likely still be cheaper than telaprevir BID or TID?

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