I think its a bit concerning that they need to play poker with potential partners.
As with most small biotech I would suggest that it isn't just that big pharma tries to take too much advantage - but also that the small biotech is unreasonable in their expectations. It is, after all, selling their child, which is, as every parent will tell you, the perfect child.
What is interesting is that it is very predictable. With the exception of a few biotechs almost all biotechs seem to fall way short of their predictions for when they will partner.
PS My guess (based upon personal experience within an entirely different industry), is that biotech management stinks at negotiations just like the technical teams I know.