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Re: drbio45 post# 3315

Wednesday, 08/25/2004 9:07:43 PM

Wednesday, August 25, 2004 9:07:43 PM

Post# of 257392
>> it says only one of the eyetech dose levels reached statistical significance but it looks like the .3 and the 1mg dose did… One of the two trials for the 1 mg dose demonstrated statistical significance (p=.0273 and p=.0035) <<

When a clinical trial tests multiple doses, the p-value threshold for statistical significance is reduced accordingly. Since EYET was testing three doses, statistical significance was defined as p<.0167 (i.e. .05/3). By this definition, the 1mg dose failed on one of the two trials.



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