With the logic that PI's have generally gotten higher log reductions (than Polymerases) perhaps 2 complimentary PI's could yield an even more staggering first day drop.
From a resistance standpoint, you might be hard-pressed to find two HCV PI’s that are genuinely complementary, so I don’t think this idea will fly.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”