"Rib should add much to early viral load declines"
tony - can you provide data to back this assertion. my understanding is that ribavirin contribues way more to decreasing relapse than knocking down virus. i saw data showing it can decrease rebound during interferon-free days prior to introduction of pegylated interferon, but given it was already soc before pegylated interferon was introduced it's going to be tough to dig up data on viral kinetics with and without rib using a potent interferon. perhaps data on daily vs 3x/week standard interferon with or without rib might give a clue. regardless, i think with a very potent agent like lambda the contribution of rib to further suppressing virus is likely to be masked - just as it seems to be in the non-rib containing arms in studies using direct antivirals where viral kinetic data without rib was superb but svr suffered due to relapse
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