I think that everyone has forgotten that Tysabri is indicated as an second line drug and Biogen is absolutely correct to use Avonex first. I'm sure Biogen is pushing Tysabri at that point because they have nothing else.
--------------------------------------INDICATIONS AND USAGE ------------------------------------- TYSABRI is an integrin receptor antagonist indicated for treatment of: Multiple Sclerosis (MS) (1.1) • As monotherapy for the treatment of patients with relapsing forms of multiple sclerosis to delay the accumulation of physical disability and reduce the frequency of clinical exacerbations. TYSABRI is generally recommended for patients who have had an inadequate response to, or are unable to tolerate, an alternate MS therapy.