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Re: genisi post# 75504

Sunday, 04/05/2009 9:22:22 AM

Sunday, April 05, 2009 9:22:22 AM

Post# of 257265
I too am not convinced clevudine will achieve SVR, but my point is if it does and there is a paradigm shift to achieve SVR then interferon combination should increase the rate of cure more than combination with other nukes because interferon as monotherapy already has a measurable (albeit low) SVR as monotherapy compared with a negligible rate for nukes. on the other hand, if chronic suppression of virus remains the goal for most then perhaps combos of 2 nukes will become popular to decrease resistance, although there will be a lot of scrutiny on safety and cost-effectiveness, especially since viread and baraclude have inhernently high barriers to resistance as monotherapy - especially in naive pts

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