I believe the synergistic effect is mainly attributed to ITMN-191 since a synergistic effect was also observed when ITMN-191 was combined with IFN+Rib (looks more like additive effect for pharmaset' drug in triple combo based on the graph you have provided). Given that the triple combo of ITMN-191 at 100q8h and 200q8h did not show a huge difference, I speculate that the ITMN-191 200q8h/R7128 500 BID conhort will likely not exceed -4.5log.
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