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Sunday, March 15, 2009 10:37:26 PM
THLD – I have a problem with slide #9 from the BIO-CEO webcast,
which purports to illustrate a strong relationship between the
oxygen level of a patient’s tumor and survival:
What’s the problem? First, these three studies were presumably cherry-picked from among hundreds of relevant cancer studies that have been published in peer-reviewed journals during the past decade. In how many of these studies was hypoxia shown to have no meaningful correlation with survival?
Second, the oxygen threshold to define hypoxia in these three charts is not constant but rather varies from 10mm Hg to 19mm Hg — in other words, the definition of hypoxia used in this slide is post hoc.
All told, I consider the above slide—an important one in the company’s TH-302 story—to be at best silly and at worst disingenuous. Caveat emptor!
which purports to illustrate a strong relationship between the
oxygen level of a patient’s tumor and survival:
What’s the problem? First, these three studies were presumably cherry-picked from among hundreds of relevant cancer studies that have been published in peer-reviewed journals during the past decade. In how many of these studies was hypoxia shown to have no meaningful correlation with survival?
Second, the oxygen threshold to define hypoxia in these three charts is not constant but rather varies from 10mm Hg to 19mm Hg — in other words, the definition of hypoxia used in this slide is post hoc.
All told, I consider the above slide—an important one in the company’s TH-302 story—to be at best silly and at worst disingenuous. Caveat emptor!
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