Thank you for bringing THLD to my attention. I'm long time "follower" of oxigene and I immediately got interested in THLD when I saw your posts. There is data coming out (see for instance recent papers in Cancer Cell) that anti-angiogenic drugs can make tumors more aggressive due to the hypoxic situation they create. This could potentially be a problem for VDAs as well. A HPA could be a very useful addition to an anti-angiogenic/VDA regiment.