>Too late for the FREEDOMS trials to test for a lower dose but regardless, it would be very difficult to do a lower dose placebo-controlled study, especially in the U.S. as you've mentioned in the quiz.<
I should have pointed out that 1.25mg is the only dose being tested in the phase-3 trial in PPMS trial called INFORMS.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”