Biotech Values

[ghmm]

For what its worth I too thought they'ld want to see if different ratios would show one drug needed to be higher then another. If 1000mg is the optimal polymerase and they intended to dose at least 200mg q8 for the protease then perhaps studying 500mg 200mg or 1000mg 100mg while it could provide some additional information may not be of much benefit.

The 1000mg dose on the Polymerase I believe was found to be the optimal dose (I believe 1500mg didn't seem to be statistically better) and the 200mg q8 protease was the maximum in treatment naive that was tested (and reported/presented) so perhaps that is the max they could do for now. Intermune has stated they have tested higher doses in the triple combo (PEG-Riba) study.

Dan Welch did say the 1 is to be followed by multiple other INFORM studies. I wonder if they are trying to gain preliminary information in a quick fashion. Also I would think that 1000mg / 200mg is the minimum necessary to even bother with a 2 drug combo so if they can't reach that then additional drugs are needed in combos to go further.