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Re: DewDiligence post# 68414

Monday, 11/24/2008 5:01:30 PM

Monday, November 24, 2008 5:01:30 PM

Post# of 257580
ITMN/INFORM Study:

On a closer rehear Dan Welch indicated there are 4 planned cohorts 56 patients total.

Given the PR on the 10th said patients were dosed (I believe in one of the presentations the 7th was said as the first day) we should now have some who have completed cohort 1.

If the second cohort is dosing lo/high for the Protease and Polymerase is there any reason why they wouldn't do 2 cohorts simultaneously (i.e. lo/high Protease-Polymerase and lo-high for Polymerase and Protease).

I got the sense INFORM-1 won't be adding cohorts and will be more to get some data for the follow-on INFORM studies which there may be several of likely international studies (given that the two agents should be in Phase 2 by that time).

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