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DewDiligence

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Re: ghmm post# 68099

Sunday, 11/02/2008 10:25:24 AM

Sunday, November 02, 2008 10:25:24 AM

Post# of 257580
>SGP VRTX – Does anyone know the significance of the 4 week lead-in?<

It allows peg-IFN and ribavirin to reach a steady-state concentration before the protease inhibitor (Telaprevir or Boceprevir) is added to the cocktail. This increases the effectiveness of peg-IFN and ribavirin in suppressing mutations that have resistance to the protease inhibitor.

“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”

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