RespireRx Pharmaceuticals Inc (fka RSPI)

[neuroinv]

Gfp: Yes, your post from a few days ago about possible mask problems looks totally on the money--congratulations. The anxiety issue is also relevant, since increases in CO2 levels can trigger panic in someone who is already anxious, altering breathing patterns--indeed it is used to induce panic attacks in tests of anxiolytics. My guess is that the both the mask-fit and anxiety issues are less likely to be relevant in RD1, simply because the experimenters have done this before, which communicates some confidence to the subject (just like a phlebotomist who has trouble hitting the vein causes anxiety to escalate, someone fumbling with the mask might not inspire confidence). Also, that kind of University setting is more likely to have repeaters in the subject group ('hey guys, that nutty professor who is figuring out ways to suffocate people is offering 50 Euros for another of those tests....could be party money for Amsterdam!') who are less likely to become anxious, because they know the drill.

We do know that the DSMB would have been hyperattuned to any mask or anxiety related artifacts because of RD2, and would have flagged them--which I suspect would have been disclosable. Though my definition of material and Cortex's may not be matching up perfectly. But at least this shows that we simply have no idea whether 900mg or 1500mg works--the data was garbage to begin with.

NeuroInvestment