>In a nutshell the cells in the oxygen deprived area send out protein messengers which trigger apoptosis (cell suicide) in the surrounding areas making the clinical condition much worse.<
Maybe this happens in the brain? I don't know because my brain physiology is horrible.
However, you need an awfully powerful microscope to find a significant amount of apoptosis in the human heart. It was all the rage for a while, but it has been shown to be virtually nonexistant (well less than 1%).