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Re: genisi post# 65024

Monday, 08/04/2008 5:12:34 PM

Monday, August 04, 2008 5:12:34 PM

Post# of 257580
>did SGP say which arm had the 9% discontinuations?<

No.

>I suppose it was the one with the highest SVR rate of 74%.<

Probably, but not necessarily. On the one hand, it does seem reasonable to infer that the delta of 8 percentage points (74% vs 66%) seen in the 48-week run-in arm relative to the 48-week arm without run-in was due to a smaller % of dropouts in the run-in arm. On the other hand, one would ordinarily expect 48-week arms to have a higher dropout rate than 28-week arms, which suggests that the 9% dropout rate could conceivably come from one of the 28-week arms.

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