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Re: tinkershaw post# 62074

Monday, 08/04/2008 9:06:44 AM

Monday, August 04, 2008 9:06:44 AM

Post# of 257253
>…on the 20% increase basis, the control group is going to need to be extremely hard to treat and get a number perhaps as low as 32% SVR, and perhaps as high as 37%.<

It looks like it will be 35-36%, but it could be a little lower or perhaps a point higher.

>However you cut it, that would be a very tough control group to treat…<

Yes, your explanation is the correct one: the patient pool in the Boceprevir trial was clearly harder to treat than the patent pool in the PROVE-1 and PROVE-2 studies. That’s why Boceprevir’s 55-56% SVR in the short-duration arms is very impressive.



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